Specifically, they recommend supplementing the infants who are exclusively or partially breastfeed with VD of 400 IU/day and for nonbreastfeeding infants consuming <1 L a day of formula, AAP recommended to supplement with the same dose of VD as well. In 2008, the American Academy of Pediatrics (AAP), to prevent rickets, increased their recommended intake of VD for infants to 400 IU/daily. It has been recommended in guidelines published since 2010 worldwide to apply VD supplements regularly. VD deficiency is a common problem all over the world, especially in newborns, the prevention of VD deficiency continues to be the priority of health services. VD deficiency is related to some factors, such as less sunlight exposure, insufficient intake of VD and absorption problems. It is a fat-soluble prohormone and a secosteroid produced in the skin after exposure to sunlight. Vitamin D (VD) is one of the basic structural elements that play an important role in various metabolic pathways that provide many functions that are vital for the organism both directly and indirectly in addition to regulating calcium and phosphorus metabolism. The infants using oral spray form vitamin D supplements have higher VD levels com- pared to oral drop form.
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